Pharmacokinetics of Indomethacin

Description

The Indometh data frame has 66 rows and 3 columns of data on the pharmacokinetics of indometacin (or, older spelling, ‘indomethacin’).

Usage

Indometh

Format

An object of class c("nfnGroupedData", "nfGroupedData", "groupedData", "data.frame") containing the following columns:

Subject

an ordered factor containing the subject codes. The ordering is according to increasing maximum response.

time

a numeric vector of times at which blood samples were drawn (hr).

conc

a numeric vector of plasma concentrations of indometacin (mcg/ml).

Details

Each of the six subjects was given an intravenous injection of indometacin.

This dataset was originally part of package nlme (Pinheiro and Bates 2000, Appendix A.12), and that has methods (including for [, as.data.frame, plot and print) for its grouped-data classes.

Source

Davidian and Giltinan (1995, table 2.1 on page 18)

Originally: Kwan, Breault, Umbenhauer, McMahon, and Duggan (1976)

References

Davidian M, Giltinan DM (1995). Nonlinear Models for Repeated Measurement Data, series Chapman & Hall/CRC Monographs on Statistics & Applied Probability. Taylor & Francis. ISBN 9780412983412.

Kwan KC, Breault GO, Umbenhauer ER, McMahon FG, Duggan DE (1976). “Kinetics of Indomethacin Absorption, Elimination, and Enterohepatic Circulation in Man.” Journal of Pharmacokinetics and Biopharmaceutics, 4(3), 255–280. doi:10.1007/bf01063617.

Pinheiro J, Bates DM (2000). Mixed-Effects Models in S and S-PLUS, series Statistics and Computing. Springer New York. ISBN 9780387989570.

See Also

SSbiexp for models fitted to this dataset.